XMail Server Lite is an open source & free mail server with an Ajaxed webmail bundled to it.
It is compatible with Window & Linux OSs with 2 different installers provided.

The server is capable of managing SMTP/ESMTP & POP3 protocols with web-based administration panel.
It supports unlimited domains/users including virtual domains & aliases.
XMail Lite also offers anti-virus integration, bayesian filters (for spam protection) & a logging functionality of all the activities.
The Webmail Lite can display folders/nested folders, has an address book, multilingual & much more.
Tip: The webmail can be downloaded & installed as a standalone product too (from here).
Requirements: Windows or Linux OS
T-dah is a free PHP webmail application which is built from the well-known Uebimiau script & offers a slick interface.
It can be up & running in a few minutes on any PHP (4 or 5) enabled server as no database is required.
The application uses the POP3 protocol & can be configured to use SMTP, PHP mail, Sendmail or Qmail for sending e-mails.

T-dah comes with several modules like:
- event calendar
- group chat
- addressbook
- folder management
It uses TinyMCE WYSIWYG editor for creating new e-mails, has an integrated search & can be translated into any language with the "language files" support.
Requirements: PHP
Compatibility: All Major Browsers